PODS® Human TGF-α Reference: PPH323-250 The product contains the polyhedrin protein co-crystalized with Human TGF-α. TGF-α is an EGF-related polypeptide growth factor, member of the EGF family, that signals through the EGF receptor. TGF-α is biologically active and seems to play a role in cell to cell interaction. This growth factor is expressed in tumours and transformed cells, but also present in normal tissues during embryogenesis and in adult tissues. Human, mouse and rat TGF-α are cross-species reactive.
Retinoid X Receptor alpha blocking peptide Reference: GTX89652-PEP Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq, Jul 28]
PODS® Human TGF-α Reference: PPH323-1000 The product contains the polyhedrin protein co-crystalized with Human TGF-α. TGF-α is an EGF-related polypeptide growth factor, member of the EGF family, that signals through the EGF receptor. TGF-α is biologically active and seems to play a role in cell to cell interaction. This growth factor is expressed in tumours and transformed cells, but also present in normal tissues during embryogenesis and in adult tissues. Human, mouse and rat TGF-α are cross-species reactive.
Retinoid X Receptor gamma blocking peptide Reference: GTX89653-PEP This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 21]
PODS® Human TGF-β1 Reference: PPH39-50 The product contains the polyhedrin protein co-crystalized with Human TGF-β1. Transforming Growth Factor beta 1 (TGF-β1) is a member of the TGF-β superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. TGF-β1 signals through SMAD proteins via the TGF-β RI and TGF-β RII receptors.
PRDM4 blocking peptide Reference: GTX89654-PEP The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 28]
PODS® Human TGF-β1 Reference: PPH39-250 The product contains the polyhedrin protein co-crystalized with Human TGF-β1. Transforming Growth Factor beta 1 (TGF-β1) is a member of the TGF-β superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. TGF-β1 signals through SMAD proteins via the TGF-β RI and TGF-β RII receptors.
SOCS5 blocking peptide Reference: GTX89655-PEP The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 28]
PODS® Human TGF-β1 Reference: PPH39-1000 The product contains the polyhedrin protein co-crystalized with Human TGF-β1. Transforming Growth Factor beta 1 (TGF-β1) is a member of the TGF-β superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. TGF-β1 signals through SMAD proteins via the TGF-β RI and TGF-β RII receptors.
LXR alpha / LXR beta blocking peptide Reference: GTX89656-PEP The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 211]
PODS® Human TGF-β2 Reference: PPH324-50 The product contains the polyhedrin protein co-crystalized with Human TGF-β2. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β2 demonstrates cross-species reactivity. TGF-β2may have an autocrine function in enhancing tumour growth by supressing immunosurveillance of tumour development.