LRP6 blocking peptide Reference: GTX89658-PEP This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 29]
PODS® Human TGF-β2 Reference: PPH324-250 The product contains the polyhedrin protein co-crystalized with Human TGF-β2. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β2 demonstrates cross-species reactivity. TGF-β2may have an autocrine function in enhancing tumour growth by supressing immunosurveillance of tumour development.
MRP4 blocking peptide Reference: GTX89659-PEP The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 28]
PODS® Human TGF-β2 Reference: PPH324-1000 The product contains the polyhedrin protein co-crystalized with Human TGF-β2. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β2 demonstrates cross-species reactivity. TGF-β2may have an autocrine function in enhancing tumour growth by supressing immunosurveillance of tumour development.
DOK5 blocking peptide Reference: GTX89660-PEP The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 28]
PODS® Human TGF-β3 Reference: PPH109-50 The product contains the polyhedrin protein co-crystalized with Human TGF-β3. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
LXR beta blocking peptide Reference: GTX89661-PEP The liver X receptors, LXRA (NR1H3; MIM 62423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 18245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 29 [PubMed 19436111]).[supplied by OMIM, Jan 21]
PODS® Human TGF-β3 Reference: PPH109-250 The product contains the polyhedrin protein co-crystalized with Human TGF-β3. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
PODS® Human TGF-β3 Reference: PPH109-1000 The product contains the polyhedrin protein co-crystalized with Human TGF-β3. Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
FHL1 blocking peptide Reference: GTX89663-PEP This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 29]
PODS® Human TNF-α Reference: PPH111-50 The product contains the polyhedrin protein co-crystalized with Human TNF-α. Tumor Necrosis Factor alpha (TNF-α) is a prototypic ligand of the TNF superfamily, a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, monocytes, macrophages, B cells, T cells, fibroblasts, and tumor cells. Thus, playing an important role in inflammation, immune system development, apoptosis, and lipid metabolism. There is significant cross-species reactivity between human and mouse cytokines.