PODS® Human Semaphorin 3C Reference: PPH322-250 The product contains the polyhedrin protein co-crystalized with Human Semaphorin 3C. Semaphorin 3C is a secreted semaphorin and potent chemorepellent during axon and vascular guidance in the development stage. Semaphorin 3C is upregulated in tumour progression and expressed in lung and neural cells.
FLVCR blocking peptide Reference: GTX89644-PEP This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 211]
PODS® Human Semaphorin 3C Reference: PPH322-1000 The product contains the polyhedrin protein co-crystalized with Human Semaphorin 3C. Semaphorin 3C is a secreted semaphorin and potent chemorepellent during axon and vascular guidance in the development stage. Semaphorin 3C is upregulated in tumour progression and expressed in lung and neural cells.
ARHGEF4 blocking peptide Reference: GTX89645-PEP Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 28]
PODS® Human SHH Reference: PPH168-50 The product contains the polyhedrin protein co-crystalized with Human SHH. Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates. There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors. SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division.
PODS® Human SHH Reference: PPH168-250 The product contains the polyhedrin protein co-crystalized with Human SHH. Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates. There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors. SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division.
AKT3 blocking peptide Reference: GTX89647-PEP The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 28]
PODS® Human SHH Reference: PPH168-1000 The product contains the polyhedrin protein co-crystalized with Human SHH. Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates. There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors. SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division.
PODS® Human TGF-α Reference: PPH323-50 The product contains the polyhedrin protein co-crystalized with Human TGF-α. TGF-α is an EGF-related polypeptide growth factor, member of the EGF family, that signals through the EGF receptor. TGF-α is biologically active and seems to play a role in cell to cell interaction. This growth factor is expressed in tumours and transformed cells, but also present in normal tissues during embryogenesis and in adult tissues. Human, mouse and rat TGF-α are cross-species reactive.