FHL1 isoform B blocking peptide Reference: GTX89636-PEP This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 29]
PODS® Human R-Spondin 3 Reference: PPH321-250 The product contains the polyhedrin protein co-crystalized with Human R-Spondin 3. R-Spondin 3, is a member of the family of Wnt modulators. All R-Spondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. R-Spondin 3 induces and regulates the proliferation and differentiation of certain stem cell populations.
FOXN1 blocking peptide Reference: GTX89637-PEP Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 28]
PODS® Human R-Spondin 3 Reference: PPH321-1000 The product contains the polyhedrin protein co-crystalized with Human R-Spondin 3. R-Spondin 3, is a member of the family of Wnt modulators. All R-Spondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. R-Spondin 3 induces and regulates the proliferation and differentiation of certain stem cell populations.
VMAT2 blocking peptide Reference: GTX89638-PEP The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 795859]). See also SLC18A1 (MIM 1932).[supplied by OMIM, Jan 211]
PODS® Human SCF Reference: PPH4-50 The product contains the polyhedrin protein co-crystalized with Human SCF. Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. Human SCF shows no activity on mouse cells, but mouse and rat SCF are active on human cells.
PODS® Human SCF Reference: PPH4-250 The product contains the polyhedrin protein co-crystalized with Human SCF. Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. Human SCF shows no activity on mouse cells, but mouse and rat SCF are active on human cells.
Cav beta 4 (C terminus) blocking peptide Reference: GTX89641-PEP This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 29]
PODS® Human SCF Reference: PPH4-1000 The product contains the polyhedrin protein co-crystalized with Human SCF. Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. Human SCF shows no activity on mouse cells, but mouse and rat SCF are active on human cells.
Clik1/STK35 blocking peptide Reference: GTX89642-PEP The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 28]
PODS® Human Semaphorin 3C Reference: PPH322-50 The product contains the polyhedrin protein co-crystalized with Human Semaphorin 3C. Semaphorin 3C is a secreted semaphorin and potent chemorepellent during axon and vascular guidance in the development stage. Semaphorin 3C is upregulated in tumour progression and expressed in lung and neural cells.