PPP2R1A blocking peptide Reference: GTX89587-PEP This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 21]
PODS® Human MCSF Reference: PPH3-250 The product contains the polyhedrin protein co-crystalized with Human MCSF. Macrophage Colony Stimulating Factor (MCSF) is a hematopoietic growth factor that is widely produced by a variety of cells. MCSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. MCSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy. Human MCSF shows activity on mouse cells, however mouse MCSF shows no activity on human cells.
FGFR1 blocking peptide Reference: GTX89588-PEP The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 28]
PODS® Human MCSF Reference: PPH3-1000 The product contains the polyhedrin protein co-crystalized with Human MCSF. Macrophage Colony Stimulating Factor (MCSF) is a hematopoietic growth factor that is widely produced by a variety of cells. MCSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. MCSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy. Human MCSF shows activity on mouse cells, however mouse MCSF shows no activity on human cells.
Asporin blocking peptide Reference: GTX89589-PEP This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 21]
PODS® Human NGF Full-Length Reference: PPH316-50 The product contains the polyhedrin protein co-crystalized with Human NGF Full-Length. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.
PODS® Human NGF Full-Length Reference: PPH316-250 The product contains the polyhedrin protein co-crystalized with Human NGF Full-Length. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.
HPS6 blocking peptide Reference: GTX89591-PEP This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 5 protein. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 6. [provided by RefSeq, Jul 28]
PODS® Human NGF Full-Length Reference: PPH316-1000 The product contains the polyhedrin protein co-crystalized with Human NGF Full-Length. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.
Cytochrome b reductase 1 blocking peptide Reference: GTX89592-PEP This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 28]
PODS® NGF-β Reference: PPH317-50 The product contains the polyhedrin protein co-crystalized with Human NGF-β. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.