Triosephosphate isomerase blocking peptide Reference: GTX89594-PEP This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 29]
PODS® NGF-β Reference: PPH317-250 The product contains the polyhedrin protein co-crystalized with Human NGF-β. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.
ADAM12 blocking peptide Reference: GTX89596-PEP This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. [provided by RefSeq, Jul 28]
PODS® NGF-β Reference: PPH317-1000 The product contains the polyhedrin protein co-crystalized with Human NGF-β. Nerve Growth Factor (NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.
BOLL blocking peptide Reference: GTX89597-PEP This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 28]
PODS® Human Nodal Reference: PPH318-50 The product contains the polyhedrin protein co-crystalized with Human Nodal. Nodal is a member of the TGF-β superfamily and signals through two receptor complexes. Nodal induces both mesoderm and endoderm and participate in anterior-posterior positioning. Nodal also induces apoptosis in susceptible cell populations through ALK7.
PDE5A blocking peptide Reference: GTX89598-PEP This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 28]
PODS® Human Nodal Reference: PPH318-250 The product contains the polyhedrin protein co-crystalized with Human Nodal. Nodal is a member of the TGF-β superfamily and signals through two receptor complexes. Nodal induces both mesoderm and endoderm and participate in anterior-posterior positioning. Nodal also induces apoptosis in susceptible cell populations through ALK7.
SCAP2 blocking peptide Reference: GTX89599-PEP The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. [provided by RefSeq, Jul 28]
PODS® Human Nodal Reference: PPH318-1000 The product contains the polyhedrin protein co-crystalized with Human Nodal. Nodal is a member of the TGF-β superfamily and signals through two receptor complexes. Nodal induces both mesoderm and endoderm and participate in anterior-posterior positioning. Nodal also induces apoptosis in susceptible cell populations through ALK7.
PODS® Human Noggin Reference: PPH304-50 The product contains the polyhedrin protein co-crystalized with Human Noggin. Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. During embryogenesis, Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) at specific times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons.