Nucleophosmin blocking peptide Reference: GTX89581-PEP This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 29]
PODS® Human LIF Reference: PPH200-250 The product contains the polyhedrin protein co-crystalized with Human LIF. Leukemia Inhibitory Factor (LIF) is a member of the interleukin-6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic differentiation, neuronal cell differentiation, kidney development, and inflammatory processes. Human LIF may also be an important factor during human embryonic stem cell (hESC) self-renewal, pluripotency, and embryonic implantation.
PODS® Human LIF Reference: PPH200-1000 The product contains the polyhedrin protein co-crystalized with Human LIF. Leukemia Inhibitory Factor (LIF) is a member of the interleukin-6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic differentiation, neuronal cell differentiation, kidney development, and inflammatory processes. Human LIF may also be an important factor during human embryonic stem cell (hESC) self-renewal, pluripotency, and embryonic implantation.
AKAP9 blocking peptide Reference: GTX89583-PEP The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 28]
PODS® Human MANF Reference: PPH315-50 The product contains the polyhedrin protein co-crystalized with Human MANF. Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF), also known as ARP and ARMET, is secreted and localized at the endoplasmic reticulum (ER) and Golgi apparatus, and expressed in brain, neuronal and certain non-neuronal tissues. MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons, which suggests that this protein may be indicated for the treatment of neural diseases, such as Parkinson’s disease.
SRD5A1 blocking peptide Reference: GTX89584-PEP Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 6736).[supplied by OMIM, Mar 28]
PODS® Human MANF Reference: PPH315-250 The product contains the polyhedrin protein co-crystalized with Human MANF. Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF), also known as ARP and ARMET, is secreted and localized at the endoplasmic reticulum (ER) and Golgi apparatus, and expressed in brain, neuronal and certain non-neuronal tissues. MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons, which suggests that this protein may be indicated for the treatment of neural diseases, such as Parkinson’s disease.
MC3 Receptor blocking peptide Reference: GTX89585-PEP This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 28]
PODS® Human MANF Reference: PPH315-1000 The product contains the polyhedrin protein co-crystalized with Human MANF. Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF), also known as ARP and ARMET, is secreted and localized at the endoplasmic reticulum (ER) and Golgi apparatus, and expressed in brain, neuronal and certain non-neuronal tissues. MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons, which suggests that this protein may be indicated for the treatment of neural diseases, such as Parkinson’s disease.
MBL2 blocking peptide Reference: GTX89586-PEP This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 28]
PODS® Human MCSF Reference: PPH3-50 The product contains the polyhedrin protein co-crystalized with Human MCSF. Macrophage Colony Stimulating Factor (MCSF) is a hematopoietic growth factor that is widely produced by a variety of cells. MCSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. MCSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy. Human MCSF shows activity on mouse cells, however mouse MCSF shows no activity on human cells.