Frizzled 8 blocking peptide Reference: GTX89473-PEP This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 28]
PODS® Human CD40 Ligand Reference: PPH25-250 The product contains the polyhedrin protein co-crystalized with Human CD40 Ligand. CD40 Ligand is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40 Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40 Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40 Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40 Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.
GOLGA3 blocking peptide Reference: GTX89474-PEP The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 21]
PODS® Human CD40 Ligand Reference: PPH25-1000 The product contains the polyhedrin protein co-crystalized with Human CD40 Ligand. CD40 Ligand is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40 Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40 Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40 Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40 Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.
Monoamine Oxidase A blocking peptide Reference: GTX89475-PEP This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 212]
PODS® Human Chemerin Reference: PPH36-50 The product contains the polyhedrin protein co-crystalized with Human Chemerin. Chemerin is a chemoattractant adipokine that is expressed in white adipose, liver, skin, and lung tissues. Chemerin is a ligand for the G protein-coupled receptor chemokine-like receptor 1 (ChemR23), which is expressed on dendritic cells, macrophages, and adipocytes. Chemerin functions to recruit macrophages to sites of tissue damage and inflammation. Chemerin is also a regulator of glucose metabolism in the liver.
NOTCH3 blocking peptide Reference: GTX89476-PEP This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 28]
PODS® Human Chemerin Reference: PPH36-250 The product contains the polyhedrin protein co-crystalized with Human Chemerin. Chemerin is a chemoattractant adipokine that is expressed in white adipose, liver, skin, and lung tissues. Chemerin is a ligand for the G protein-coupled receptor chemokine-like receptor 1 (ChemR23), which is expressed on dendritic cells, macrophages, and adipocytes. Chemerin functions to recruit macrophages to sites of tissue damage and inflammation. Chemerin is also a regulator of glucose metabolism in the liver.
LDB3 blocking peptide Reference: GTX89478-PEP This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 8-12 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 5-6 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 21]
PODS® Human Chemerin Reference: PPH36-1000 The product contains the polyhedrin protein co-crystalized with Human Chemerin. Chemerin is a chemoattractant adipokine that is expressed in white adipose, liver, skin, and lung tissues. Chemerin is a ligand for the G protein-coupled receptor chemokine-like receptor 1 (ChemR23), which is expressed on dendritic cells, macrophages, and adipocytes. Chemerin functions to recruit macrophages to sites of tissue damage and inflammation. Chemerin is also a regulator of glucose metabolism in the liver.
GOLGA6 / GLP blocking peptide Reference: GTX89479-PEP This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, which are greater than 9% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosomal rearrangements that underlie genomic disease. This gene is a member of the golgin gene family, whose protein products localize to the Golgi apparatus. The majority of the related gene copies are thought to be transcribed pseudogenes. It is not known whether this gene is a pseudogene or if it encodes a golgin protein. [provided by RefSeq, Jul 28]
PODS® Human CNTF Reference: PPH59-50 The product contains the polyhedrin protein co-crystalized with Human CNTF. Ciliary Neurotrophic Factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis. CNTF also plays an important protective role during nervous system injury.