TNFRSF14 blocking peptide Reference: GTX89465-PEP The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq, Jul 28]
PODS® Human BMP-4 Reference: PPH56-250 The product contains the polyhedrin protein co-crystalized with Human BMP-4. Bone Morphogenic Protein 4 (BMP-4) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth.
DARC blocking peptide Reference: GTX89467-PEP The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
PODS® Human BMP-4 Reference: PPH56-1000 The product contains the polyhedrin protein co-crystalized with Human BMP-4. Bone Morphogenic Protein 4 (BMP-4) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth.
PODS® Human BMP-10 Reference: PPH308-50 The product contains the polyhedrin protein co-crystalized with Human BMP-10. Bone Morphogenic Protein 10 (BMP-10) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. In dermal endothelial cells, BMP-10 plays a role in migration, proliferation, and gene expression.
FOXC1 (internal) blocking peptide Reference: GTX89469-PEP This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 28]
PODS® Human BMP-10 Reference: PPH308-250 The product contains the polyhedrin protein co-crystalized with Human BMP-10. Bone Morphogenic Protein 10 (BMP-10) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. In dermal endothelial cells, BMP-10 plays a role in migration, proliferation, and gene expression.
OSBPL10 blocking peptide Reference: GTX89470-PEP This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 21]
PODS® Human BMP-10 Reference: PPH308-1000 The product contains the polyhedrin protein co-crystalized with Human BMP-10. Bone Morphogenic Protein 10 (BMP-10) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. In dermal endothelial cells, BMP-10 plays a role in migration, proliferation, and gene expression.
beta 2 Adrenergic Receptor blocking peptide Reference: GTX89471-PEP This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 28]
PODS® Human CD40 Ligand Reference: PPH25-50 The product contains the polyhedrin protein co-crystalized with Human CD40 Ligand. CD40 Ligand is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40 Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40 Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40 Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40 Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.