VDP / p115 blocking peptide Reference: GTX89480-PEP The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM13 and giantin in a sequential manner. [provided by RefSeq, Jul 28]
PODS® Human CNTF Reference: PPH59-250 The product contains the polyhedrin protein co-crystalized with Human CNTF. Ciliary Neurotrophic Factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis. CNTF also plays an important protective role during nervous system injury.
STX1A/STX1B blocking peptide Reference: GTX89481-PEP This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 29]
PODS® Human CNTF Reference: PPH59-1000 The product contains the polyhedrin protein co-crystalized with Human CNTF. Ciliary Neurotrophic Factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis. CNTF also plays an important protective role during nervous system injury.
Cofilin 2 blocking peptide Reference: GTX89482-PEP This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 29]
PODS® Human CTGF Reference: PPH327-50 The product contains the polyhedrin protein co-crystalized with Human CTGF. Connective Tissue Growth Factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (FGF-2) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.
MEFV blocking peptide Reference: GTX89483-PEP This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 28]
PODS® Human CTGF Reference: PPH327-250 The product contains the polyhedrin protein co-crystalized with Human CTGF. Connective Tissue Growth Factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (FGF-2) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.
NHERF2 blocking peptide Reference: GTX89484-PEP This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 211]
PODS® Human CTGF Reference: PPH327-1000 The product contains the polyhedrin protein co-crystalized with Human CTGF. Connective Tissue Growth Factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (FGF-2) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.
Rhophilin 2 (Internal) blocking peptide Reference: GTX89485-PEP This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 29]
PODS® Human DKK-1 Reference: PPH309-50 The product contains the polyhedrin protein co-crystalized with Human DKK-1. Dickkopf related protein 1 (DKK-1) is a member of the Dickkopf family of proteins that includes DKK-1, DKK-2, DKK-3, DKK-4, and a related protein Soggy. DKK-1 and DKK-4 are well documented antagonists of the canonical Wnt/β-catenin signaling pathway by forming inhibitory complexes composed of the Frizzled proteins and one of two low-density lipoprotein receptor-related proteins, LRP5 or LRP6. DKK-1 antagonizes Wnt by forming ternary complexes of LRP5/6 with Kremen1 or Kremen2. The balance between Wnt signaling and DKK-1 inhibition is critical for bone formation and homeostasis, resulting that insufficient or excess of DKK-1 activity in bone leads to an increased or decreased bone density, respectively. In adults, DKK-1 is expressed in osteoblasts, osteocytes, and neurons.