Alpha 2 Antiplasmin blocking peptide Reference: GTX88657-PEP This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 29]
Recombinant Mouse IL-36 γ (Animal-Free) Reference: GFM81AF-1000 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
RAB23 blocking peptide Reference: GTX88658-PEP The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 28]
Recombinant Human IP-10 / CXCL10 Reference: GFH127-5 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
MSH5 blocking peptide Reference: GTX88660-PEP This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 211]
Recombinant Human IP-10 / CXCL10 Reference: GFH127-25 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
Recombinant Human IP-10 / CXCL10 Reference: GFH127-100 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
Recombinant Human IP-10 / CXCL10 Reference: GFH127-1000 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
PMP70 blocking peptide Reference: GTX88667-PEP The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 28]
Recombinant Mouse IP-10 / CXCL10 Reference: GFM38-5 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.