ABCC11 blocking peptide Reference: GTX88673-PEP The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 28]
Recombinant Mouse IP-10 / CXCL10 Reference: GFM38-25 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
N-RAS blocking peptide Reference: GTX88676-PEP This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 211]
Recombinant Mouse IP-10 / CXCL10 Reference: GFM38-100 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
Recombinant Mouse IP-10 / CXCL10 Reference: GFM38-1000 Interferon γ-induced protein 10 (IP-10), also known as CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon γ (IFN-γ). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and Natural Killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus.
Recombinant Human ITAC / CXCL11 Reference: GFH128-5 Interferon-inducible T cell α chemoattractant (ITAC), also known as CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. ITAC gene expression is induced by interferons α (IFN-α), β (IFN-β), and γ (IFN-γ). ITAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. ITAC functions as a chemoattractant for interleukin-2 (IL-2)-activated T cells.
Recombinant Human ITAC / CXCL11 Reference: GFH128-20 Interferon-inducible T cell α chemoattractant (ITAC), also known as CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. ITAC gene expression is induced by interferons α (IFN-α), β (IFN-β), and γ (IFN-γ). ITAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. ITAC functions as a chemoattractant for interleukin-2 (IL-2)-activated T cells.
AKAP10 blocking peptide Reference: GTX88680-PEP This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 212]
Recombinant Human ITAC / CXCL11 Reference: GFH128-100 Interferon-inducible T cell α chemoattractant (ITAC), also known as CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. ITAC gene expression is induced by interferons α (IFN-α), β (IFN-β), and γ (IFN-γ). ITAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. ITAC functions as a chemoattractant for interleukin-2 (IL-2)-activated T cells.