Bradykinin B1 receptor blocking peptide Reference: GTX88647-PEP Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 211]
Recombinant Mouse IL-36 γ Reference: GFM81-20 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
TRPV3 (aa762-773) blocking peptide Reference: GTX88648-PEP This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 4 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 212]
Recombinant Mouse IL-36 γ Reference: GFM81-100 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
BIN1 blocking peptide Reference: GTX88650-PEP This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 211]
Recombinant Mouse IL-36 γ Reference: GFM81-1000 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
TRPC4 blocking peptide Reference: GTX88652-PEP This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 211]
Recombinant Mouse IL-36 γ (Animal-Free) Reference: GFM81AF-5 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Monoglyceride lipase blocking peptide Reference: GTX88653-PEP This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 212]
Recombinant Mouse IL-36 γ (Animal-Free) Reference: GFM81AF-20 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Recombinant Mouse IL-36 γ (Animal-Free) Reference: GFM81AF-100 Interleukin-36 γ (IL-36 γ) is a member of the interleukin-1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36G binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kappaB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.