Category: Proteins & Peptides

Active filters

MYH3 blocking peptide

Reference: GTX32147-PEP

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 28]

GLIS2 blocking peptide

Reference: GTX32148-PEP

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p12 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p12. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 21]

INHBA (recombinant)

Reference: 32091-10

Source: Active recombinant INHBA expressed in HEK293 cells • Amino acids: 311-426 • MW: 13 kDa

INHBA (recombinant)

Reference: 32091-50

Source: Active recombinant INHBA expressed in HEK293 cells • Amino acids: 311-426 • MW: 13 kDa

SLC29A2 blocking peptide

Reference: GTX32150-PEP

The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 28]

CXCL12α (human, recombinant)

Reference: 32093-10

Source: Recombinant human N-terminal His-tagged CXCL12α expressed in E. coli • Amino acids: 22-89 • MW: 10 kDa

SLC29A3 blocking peptide

Reference: GTX32151-PEP

This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 21]

CXCL12α (human, recombinant)

Reference: 32093-20

Source: Recombinant human N-terminal His-tagged CXCL12α expressed in E. coli • Amino acids: 22-89 • MW: 10 kDa

HOPX blocking peptide

Reference: GTX32152-PEP

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 29]

Back to top