Category: Proteins & Peptides

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Citrullinated GFAP (human, recombinant)

Reference: 28622-100

Source: Recombinant N-terminal histidine-tagged GFAP expressed in E. coli. Citrullinated with recombinant human PAD2 • Amino acids: 2-432 • MW: 51.9 kDa

Dectin-1 blocking peptide

Reference: GTX31853-PEP

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 28]

β-Catenin (human, recombinant)

Reference: 28780-100

Source: Recombinant N-terminal His-TEV-tagged human β-catenin (138-781) purified from E. coli • Amino acids: 138-781 • MW: 72.4 kDa

ABCA7 blocking peptide

Reference: GTX31856-PEP

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 28]

PAD4 (mouse, recombinant)

Reference: 28910-100

Source: Active recombinant N-terminal His-tagged protein expressed in insect cells • Amino acids: 2-666 (full length) • MW: 76.08 kDa

CASK blocking peptide

Reference: GTX31858-PEP

This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 21]

FSP1 (human, recombinant)

Reference: 29611-50

Source: Active recombinant N-terminal His-tagged human FSP1 expressed in E. coli • Amino acids: 2-373 • MW: 42.5 kDa

p57 Kip2 blocking peptide

Reference: GTX31859-PEP

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 21]

PHLPP1 blocking peptide

Reference: GTX31861-PEP

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 211]

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