Category: Proteins & Peptides

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Citrullinated Histone H2B (human, recombinant)

Reference: 30133-100

Source: Recombinant human histone H2B type 1-A expressed in E. coli, citrullinated with human recombinant PAD4 • Amino acids: 2-127 (full length) • MW: 14.04 kDa

FLT3 blocking peptide

Reference: GTX31863-PEP

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 215]

Citrullinated IL-6 (human, recombinant)

Reference: 30173-100

Source: Recombinant human N-terminal His-tagged IL-6 expressed in HEK293 cells, citrullinated by PAD4 • Amino acids: 30-212 • MW: 20.9 kDa

KEAP1 blocking peptide

Reference: GTX31864-PEP

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 28]

IL-6 (human, recombinant)

Reference: 30174-100

Source: Recombinant N-terminal His-tagged IL-6 expressed in Expi293F cells • Amino acids: 30-212 • MW: 20.9 kDa

BATF blocking peptide

Reference: GTX31865-PEP

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 28]

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