Glucose-6-phosphate Isomerase (human, recombinant) Reference: 18279-100 Recombinant C-terminal His-tagged protein expressed in E. coli • One unit is defined as the amount of enzyme required to reduce 1 µmol of NADP+ to NADPH per minute at 25°C in 50 mM Triethanolamine, pH 7.6, containing 1 mM MgCl2
FOXO4 blocking peptide Reference: GTX31807-PEP This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 21]
COX-2 (ovine, recombinant) Reference: 18356-5 Recombinant protein expressed in Sf21 cells using the Baculovirus system • One unit is defined as the amount of enzyme required to consume 1 nmol of oxygen per minute 37°C in 100 mM Tris, pH 8.0, containing 100 µM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 µM hematin.
FOXO4 blocking peptide Reference: GTX31808-PEP This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 21]
Human Fibrinogen (PAD2 Citrullinated) Reference: 18473-1 Source: Purified from human plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV, citrullinated with human recombinant PAD2 • MW: α chain isoform 1 (95 kDa), α chain isoform 2 (69.8 kDa), β chain (55.9k Da), and isoform γ-B chain (51.5 kDa)
NOD1 blocking peptide Reference: GTX31810-PEP This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 1 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 29]
HDAC8 (human recombinant) Reference: 19380-50 Source: Active recombinant C-terminal His-tag expressed in E. coli • MW: 45.3 kDa • HDAC8 is a Class I HDAC that catalyzes the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restricting access to transcription factors, and suppression of transcription. It can also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands.
SRP1 blocking peptide Reference: GTX31811-PEP The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 6-1 proteins. Small molecules (up to 7 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 212]
Pertussis Toxin (islet-activating protein) Reference: 19546-50 A toxin that is used to study Gi/o-linked GPCR signaling in cells and EAE in animals; completely blocks the ability of AC to be inhibited by GPCRs that signal through Gi subunits
KPNA2 blocking peptide Reference: GTX31812-PEP The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 1 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV4 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 28]
Citrullinated Core Histones (bovine) Reference: 20582-100 A mixture of H1, H2A, H2B, H3, and H4 histones
KPNA4 blocking peptide Reference: GTX31813-PEP The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV4 T antigen. [provided by RefSeq, Jul 28]