PCAF Histone Acetyltransferase Reference: 10009115-100 Source: Active recombinant GST-tagged protein expressed in E. coli · MW: ~40 kDa. PCAF belongs to the GCN5/PCAF family of nuclear HATs. Cayman’s PCAF preparation contains 165 amino acids from the HAT activity domain of human PCAF fused to GST at the N-terminus. Enzyme activity was determined using a fluorescent HAT assay and is comparable to that found in the literature.
HDAC1 (human, recombinant) Reference: 10009231-1 Source: 50 µg of full length recombinant C-terminal His- and FLAG-tagged protein expressed in baculovirus expression system • MW: 57 kDa • HDAC1 is a Class I HDAC that catalyzes the deacetylation of core histones and other non-histone proteins to control complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.
HDAC3/NCOR2 (human, recombinant) Reference: 10009232-1 Source: 50 µg of a complex of full-length recombinant C-terminal His-tagged HDAC3 and recombinant N-terminal GST-tagged NCOR2 amino acids 395-489, co-expressed in baculovirus expression system · Mr: 49.7 kDa (HDAC3); 37.6 kDa (NCOR2) • HDAC3 is a Class I HDAC that is inactive alone and requires binding with the deacetylase activation domain of NcoR2 for activation.
ATG4C blocking peptide Reference: GTX31585-PEP Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 28]
HDAC2 (human, recombinant) Reference: 10009377-1 Source: 50 µg of full-length recombinant C-terminal His-tagged HDAC2 expressed in baculovirus expression system • Full length • MW: 56 kDa
SOX18 blocking peptide Reference: GTX31587-PEP This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 28]
HDAC5 (human, recombinant) Reference: 10009379-1 Source: 10 µg of recombinant C-terminal His-tagged protein expressed in baculovirus expression system · Mr: 51 kDa • HDAC5 is a Class IIa HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates.
NOX4 blocking peptide Reference: GTX31588-PEP This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 29]
HDAC6 (human, recombinant) Reference: 10009465-1 Source: 50 µg of full-length recombinant N-terminal GST-tagged protein expressed in baculovirus expression system · Mr: 159 kDa • HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates.
E2F3 blocking peptide Reference: GTX31589-PEP This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 213]