Category: Proteins & Peptides

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Leukotriene A4 Hydrolase (human, recombinant)

Reference: 10007817-100

Source: Active recombinant C-terminal His-tagged enzyme expressed in E. coli • MW: ~69 kDa • A bifunctional zinc metalloenzyme that converts LTA4 into LTB4, a potent neutrophil chemoattractant; potential drug target for a variety of indications associated with leukocyte infiltration to sites of inflammation; has application for the screening of inhibitors of LTB4 synthesis

DOCK8 blocking peptide

Reference: GTX31578-PEP

This gene encodes a member of the DOCK18 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 21]

SREBP1 blocking peptide

Reference: GTX31579-PEP

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]

Prostaglandin F Synthase (human, recombinant)

Reference: 10007940-100

Source: Active recombinant C-terminal His-tagged protein expressed in E. coli · Mr: ~37 kDa · Protein concentration: 0.8 mg/ml • Human PGFS catalyzes the isomerization of PGH2 to PGF2a (PGH2 9,11-endoperoxide reductase activity), as well as the formation of 11b-PGF2a from PGD2 (PGD2 11-ketoreductase activity) in the presence of NADPH. This enzyme also exhibits reductase activities toward carbonyl compounds such at nitroacetophenone, nitrobenzaldehyde, and 9,10-phenanthrene quinine (PQ).

SREBP2 blocking peptide

Reference: GTX31580-PEP

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq, Jul 28]

15-hydroxy Prostaglandin Dehydrogenase (human, recombinant)

Reference: 10007950-100

Source: Active human recombinant N-terminal GST-tagged protein expressed in E. coli • MW: 55 kDa • NAD+-dependent 15-PGDH catalyzes the oxidation of PGs to 15-keto metabolites that have greatly reduced biological activity. Three different studies have shown an inverse correlation between 15-PGDH expression and cell proliferation in colon, breast, and thyroid cells.

PINK1 blocking peptide

Reference: GTX31581-PEP

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 28]

PHLP blocking peptide

Reference: GTX31582-PEP

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 28]

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