Quote Prostaglandin F2α 1,11-lactone
PGF2α 1,11-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone by plasma esterases readily produces free PGF2α in rats and monkeys, but not in humans.(1170) PGF2α 1,11-lactone is active as an antifertility agent with greatly reduced vasoactivity compared to PGF2α.(1170)
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Reference:
16110-1
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