ICG Isothiocyanate

ICG Isothiocyanate is an amine-reactive form of near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging. NIR fluorescence allows to observe the deep image from the surface of skin and being utilized in a wide range of research fields. The maxima of Ex/Em values are at 785/812 nm. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical property. Isothiocyanates are moderately reactive but quite stable in water and most organic solvents. Isothiocyanates react to primary amine to form reasonably stable thiourea linkage. Whereas labeling of protein with NHS esters can typically be done at pH 8.3, conjugation for isothiocyanates usually require pH above 9. We offer ICG isothiocyanate for labeling of antibodies, peptides, proteins, ligands, and amplification substrates optimized for cellular labeling and NIR imaging.