Quote O-1602
An agonist of GPR55 (EC50 = 13 nM in a GTPγS binding assay); selective for GPR55 over CB1 and CB1 receptors (EC50s = >30 µM for both in GTPγS binding assays); reduces growth of Mz-ChA-1, HuCCT-1, CC-LP-1, and SG231 cholangiocarcinoma cells at 50 µM; reduces tumor growth in a Mz-ChA-1 mouse xenograft model at 10 mg/kg per day; increases food intake and fat mass in rats in a GPR55-independent manner; reduces movement-induced firing of nociceptive C fibers in a rat model of inflammatory joint pain
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Reference:
10006803-25
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