Quote DL-threo-PDMP (hydrochloride)
A PDMP mixture containing D-threo (1R,2R) and L-threo (1S,2S) PDMP; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity
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Reference:
10005276-5
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