Quote Reversine
A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1 (IC50s = 6 and 2.8 nM for its kinase domain and full-length version, respectively); induces autophagy in WRO human follicular thyroid cancer cells; decreases Akt/mTOR signaling,
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Reference:
10004412-10
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