Ascorbic acid 6-palmitate

Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases.