Quote Geldanamycin
Antibiotic. Potent antitumor compound. pp60src tyrosine kinase inhibitor. Inhibits c-mycgene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src and yes. Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Destabilizes several oncogene and proto-oncogene products. Potent nuclear hormone receptor family inhibitor.
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Reference:
BVT-0196-M001
Brand: