Auranofin

Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway. Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5. Potent thioredoxin reductase (TrxR) inhibitor. Induces mitochondrial membrane permeability transition. Anti-cancer compound with anti-proliferative activity. Shown to induce apoptosis and necrosis. STAT3 and telomerase activity inhibitor. Proteasomal deubiquitinase inhibitor. Antibiotic, antiviral and antiparasitic compound. Immunosuppressive.