Quote SB431542
SB431542 suppresses TGF-β-induced proliferation of human osteosarcoma cells. SB431542 treatment of glioma cultures inhibited proliferation, TGF-β-mediated morphologic changes, and cellular motility. Small molecule inhibitors of TGF-β receptors may offer a novel therapy for malignant gliomas by reducing cell proliferation, angiogenesis, and motility.
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Reference:
SM33-10
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