SB216763

SB216763 protects both central and peripheral nervous system neurones in culture from death induced by reduced PI 3-kinase pathway activity. Treatment of primary neural progenitor cells with SB216763 resulted in an increase in the percentage of TuJ1-positive immature neurons, suggesting an inhibitory role of GSK3 in embryonic neurogenesis. It stimulates glycogen synthesis in Chang human liver cells. SB216763 treatment reduces cell viability in a dose-dependent manner, and leads to significant increase in apoptosis due to the specific down regulation of GSK-3 beta.