SAHA

Experiments suggest that SAHA causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. SAHA alters gene transcription and induces cell cycle arrest and/or apoptosis in a wide variety of transformed cells. It suppresses cell growth in a range of cancer cell lines, induces apoptosis in cutaneous T-cell lymphoma cells in-vitro. This small molecule improves reprogramming efficiency after transduction of iPSC transcription factors in mouse embryonic fibroblasts.

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