GLPG1837

A CFTR potentiator; increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508del and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay; increases forskolin-induced conductivity of patient-derived bronchial epithelial cells expressing both F508del- and G551D-mutant CFTRs (EC50 = 159 nM in a TECC assay)

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