Quote Mecillinam
A β-lactam antibiotic; active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively); active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine; binds to PBP2 over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay; efficacious against susceptible E. coli strains in a systemic mouse model of infection (PD50s = ≤0.39-6.4 mg/kg)
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Reference:
9002008-10
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