Thonzonium (bromide)

A monocationic surfactant with diverse biological activities; an inhibitor of F. tularensis AcpB (Ki = 0.59 µM) and C. albicans V-ATPase (EC50 = 69 µM); inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs; inhibits bone resorption by mature osteoclasts at 100 and 200 nM; prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day; induces mortality in C. oncophora, O. ostertagi, H. contortus, and T. circumcincta (EC50s = 4.5, 10.8, 5.1, and 6.7 µM, respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s = 9.2 and 5.7 µM, respectively)