Quote VUF 5574
An adenosine A3 receptor antagonist (Ki = 4.03 nM for the recombinant human receptor); >2,500-fold selective for adenosine A3 over A1 and A2A receptors; decreases adenosine-induced phosphorylation of ERK1/2 in isolated porcine coronary artery smooth muscle cells at 100 nM; increases oxygen-glucose deprivation-induced reductions in the amplitude of field EPSPs in a rat hippocampal slice model of ischemia at 100 nM; reduces sodium nitroprusside-induced heart rate increases in rats at 2 µg intracisternally
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Reference:
27676-10
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