5-Azacytidine Reference: SM07-50 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (DNMT), forming covalent adducts with cellular DNMT1 depleting enzyme activity. This small molecule enhances differentiation to cardiomyocytes from human embryonic stem cells. 5-Azacytidine also increases reprogramming efficiency of mouse fibroblasts to pluripotent stem cells.
5-Azacytidine Reference: SM07-200 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (DNMT), forming covalent adducts with cellular DNMT1 depleting enzyme activity. This small molecule enhances differentiation to cardiomyocytes from human embryonic stem cells. 5-Azacytidine also increases reprogramming efficiency of mouse fibroblasts to pluripotent stem cells.
A769662 Reference: SM08-2 A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.
A769662 Reference: SM08-10 A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.
A769662 Reference: SM08-50 A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.
A769662 Reference: SM08-200 A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.
ALK5 Inhibitor II Reference: SM09-1 ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).
ALK5 Inhibitor II Reference: SM09-5 ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).
ALK5 Inhibitor II Reference: SM09-10 ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).
ALK5 Inhibitor II Reference: SM09-25 ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).
ALK5 Inhibitor II Reference: SM09-50 ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).
BI-D1870 Reference: SM10-1 BI-D1870 induces apoptosis, although preferentially, in a p21-deficient background. BI-D1870 also induces a strong transcription and p53-independent accumulation of p21 protein and protects cells from gamma irradiation-induced apoptosis, driving them into senescence even in the absence of gamma irradiation.