AM630 Reference: 10006974-50 An inverse agonist at CB2 and partial agonist at CB1 receptors; binds selectively to CB2 over CB1 receptors (Kis = 31.2 and 5,152 nM, respectively); blocks the antinociceptive effects of cannabinoids; decreases proliferation and induces cell cycle arrest in renal cell carcinoma cells
Gilvocarcin M Reference: 25762-2,5 An antibiotic; active against S. aureus bacteria at 32 µg/ml; inhibits growth of KB cells (IC50 = 0.52 µg/ml); intercalates into bacteriophage PM2 DNA; toxic to rats (LD50 = 450 mg/kg, i.v.)
Prostaglandin A2 MaxSpec® Standard Reference: 10007199-100 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications,
Ajoene Reference: 26242-2,5 A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma cells (IC50 = 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM); reduces tumor growth in a B16/BL6 mouse model of melanoma at 25 µg/kg every other day and decreases the number of lung metastases when administered prior to tumor cell inoculation at 1-25 µg/g; inhibits ADP- or collagen-induced platelet aggregation in isolated baboon platelets at 75-100 µg/ml and in platelet-rich plasma isolated from baboons at 25 mg/kg; prevents thrombus formation on damaged arterial walls in heparinized pigs in an in situ model of thrombogenesis at 25 mg/kg; reduces high-fat diet-induced hepatic steatosis, histopathological markers of liver damage, TBARS formation, and protein oxidation in a mouse model of NAFLD
13,14-dihydro-15-keto Prostaglandin A2 MaxSpec® Standard Reference: 10007200-100 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications,
Lachnone A Reference: 26462-2,5 A fungal metabolite; inactive against P. falciparum, C. albicans, and M. tuberculosis; not cytotoxic to KB or BC-1 cells