AZD 1981 Reference: 20763-25 A selective DP2 receptor antagonist with a pIC50 value of 8.4; blocks functional responses in eosinophils, Th2 cells, and basophils
AZD 1981 Reference: 20763-5 A selective DP2 receptor antagonist with a pIC50 value of 8.4; blocks functional responses in eosinophils, Th2 cells, and basophils
Dicoumarol Reference: 20764-1 A competitive NQO1 inhibitor; inhibits recombinant hNQO1 (IC50s =2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively); has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cell lines (IC50s = 52 and 19 μM, respectively); inhibits SAPK activity in HEK293 cells (IC50 = 19-33 μM); inhibits TNF-α and LPS-induced NF-κB activation; has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM)
Dicoumarol Reference: 20764-10 A competitive NQO1 inhibitor; inhibits recombinant hNQO1 (IC50s =2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively); has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cell lines (IC50s = 52 and 19 μM, respectively); inhibits SAPK activity in HEK293 cells (IC50 = 19-33 μM); inhibits TNF-α and LPS-induced NF-κB activation; has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM)
Dicoumarol Reference: 20764-5 A competitive NQO1 inhibitor; inhibits recombinant hNQO1 (IC50s =2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively); has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cell lines (IC50s = 52 and 19 μM, respectively); inhibits SAPK activity in HEK293 cells (IC50 = 19-33 μM); inhibits TNF-α and LPS-induced NF-κB activation; has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM)
Pizotifen (malate) Reference: 20765-1 A triptan with high affinity for serotonin and dopamine receptors (Kis = 7.94 and 2.4 nM for 5-HT2C and D2, respectively)