K-Ras(G12C) Inhibitor 12 Reference: 20118-1 An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
K-Ras(G12C) Inhibitor 12 Reference: 20118-10 An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
K-Ras(G12C) Inhibitor 12 Reference: 20118-25 An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
K-Ras(G12C) Inhibitor 12 Reference: 20118-5 An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
Chlorisondamine (iodide) Reference: 20119-1 A long-lasting antagonist of nAChRs (IC50 = 1.8 µM) and ganglion blocker; decreases nicotine-induced dopamine release in rat striatal synaptosomes at concentrations ranging from 0-100 µM; a dose of 10 mg/kg blocks nicotine-induced stimulant activity for at least five weeks; prevents acquisition of conditioned taste aversion in rats when used at a dose of 5 µg, i.c.v.; inhibits autonomic ganglia when used at a dose of 50 mg/kg in cats
Chlorisondamine (iodide) Reference: 20119-10 A long-lasting antagonist of nAChRs (IC50 = 1.8 µM) and ganglion blocker; decreases nicotine-induced dopamine release in rat striatal synaptosomes at concentrations ranging from 0-100 µM; a dose of 10 mg/kg blocks nicotine-induced stimulant activity for at least five weeks; prevents acquisition of conditioned taste aversion in rats when used at a dose of 5 µg, i.c.v.; inhibits autonomic ganglia when used at a dose of 50 mg/kg in cats