Ethynodiol Diacetate Reference: 29854-5 A synthetic progestogen; prevents the development of osteoporosis in ovariectomized rats at 9 µg/animal per day; inhibits copulatory ovulation in rabbits
2,5-Deoxyfructosazine (hydrochloride) Reference: 18662-1 A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry; has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM)
Ethynodiol Diacetate Reference: 29854-500 A synthetic progestogen; prevents the development of osteoporosis in ovariectomized rats at 9 µg/animal per day; inhibits copulatory ovulation in rabbits
2,5-Deoxyfructosazine (hydrochloride) Reference: 18662-5 A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry; has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM)
Fluticasone Furoate Reference: 29878-1 A synthetic glucocorticoid; selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as ERα and ERβ in scintillation proximity assays (EC50s = >10,000 nM); reduces LPS-induced increases in TNF-α production in human PBMCs (EC50 = 0.12 nM); decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue in vitro at 100 nM; reduces ovalbumin-induced increases in BALF eosinophil infiltration in a rat model of allergic inflammation at 30 µg/animal intrathecally
2,5-Deoxyfructosazine (hydrochloride) Reference: 18662-500 A pyrazine derivative that is used as a flavoring agent in the food and tobacco industry; has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM)
Fluticasone Furoate Reference: 29878-10 A synthetic glucocorticoid; selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as ERα and ERβ in scintillation proximity assays (EC50s = >10,000 nM); reduces LPS-induced increases in TNF-α production in human PBMCs (EC50 = 0.12 nM); decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue in vitro at 100 nM; reduces ovalbumin-induced increases in BALF eosinophil infiltration in a rat model of allergic inflammation at 30 µg/animal intrathecally
MCLA (hydrochloride) Reference: 18673-1 A chemiluminescent probe for superoxide production by activated leukocytes