Talampanel Reference: 15341-5 An allosteric AMPA receptor antagonist (IC50 = 2.5 µM); reduces the firing rate of spinal neurons in rats by 68% at 10 mg/kg following AMPA administration; protective in mouse models of MES-induced (ED50 = 8.6 mg/kg) and 4-aminopyridine-induced seizures (ED50 = 8.4 mg/kg); potentiates the effects of diazepam in MES- and metrazole-induced seizure models at 2 mg/kg; reduces lesion size in rat and mouse models of focal ischemia
Talampanel Reference: 15341-50 An allosteric AMPA receptor antagonist (IC50 = 2.5 µM); reduces the firing rate of spinal neurons in rats by 68% at 10 mg/kg following AMPA administration; protective in mouse models of MES-induced (ED50 = 8.6 mg/kg) and 4-aminopyridine-induced seizures (ED50 = 8.4 mg/kg); potentiates the effects of diazepam in MES- and metrazole-induced seizure models at 2 mg/kg; reduces lesion size in rat and mouse models of focal ischemia
Phortress Reference: 15342-10 A lysyl amide prodrug of the benzothiazole 5-fluoro 203, a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest
Phortress Reference: 15342-5 A lysyl amide prodrug of the benzothiazole 5-fluoro 203, a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest