Reagents (2)

Isokotanin B

Reference: 25082-2,5

€0.00 (tax incl.)

A fungal metabolite; dietary administration reduces C. hemipterus larvae feeding by 21% at 100 ppm

Aspochalasin M

Reference: 25087-2,5

€0.00 (tax incl.)

A fungal metabolite; inhibits the growth of HL-60 cells (IC50 = 20 µM)

Petromurin C

Reference: 25089-2,5

€0.00 (tax incl.)

A fungal metabolite; cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml); has activity against T. foetus in vitro (IC50 = 100 μg/ml)

Unguisin B

Reference: 25115-2,5

€0.00 (tax incl.)

A cyclic heptapeptide containing GABA

A fungal metabolite; inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, at 100 ppm; inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone...

Lobaric Acid

Reference: 25205-2,5

€0.00 (tax incl.)

A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer...

Acetylaszonalenin

Reference: 25207-2,5

€0.00 (tax incl.)

A fungal metabolite; NK1 antagonist (Ki = 170 μM)

Palitantin

Reference: 25208-2,5

€0.00 (tax incl.)

A fungal metabolite; inhibits HIV-1 integrase (IC50s = 350 and 268 µM for 3’-processing and strand transfer activity, respectively); has been used as a standard for dereplication of natural products

Leucanicidin

Reference: 25479-2,5

€0.00 (tax incl.)

A macrolide bacterial metabolite; toxic to L. separata fourth instar larvae at 20 ppm; toxic to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 µg/ml)

Setosusin

Reference: 25484-2,5

€0.00 (tax incl.)

A fungal metabolite; reduces Aβ aggregate-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM); induces tremors in mice at 30 mg/kg

Herbimycin C

Reference: 25485-2,5

€0.00 (tax incl.)

A bacterial metabolite; cytotoxic to HeLa and Ehrlich cells (IC50s = 7.3 and 1.2 μg/ml, respectively)

Berninamycin D

Reference: 25513-2,5

€0.00 (tax incl.)

A cyclic thiopeptide fungal metabolite

Luteoreticulin

Reference: 25515-2,5

€0.00 (tax incl.)

A nitro-containing bacterial metabolite; has mosquitocidal activity against A. aegypti at 6.25 mg/L; has nematocidal activity against C. elegans

Pestalotin

Reference: 25516-2,5

€0.00 (tax incl.)

A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3...

Filipin II

Reference: 25521-2,5

€0.00 (tax incl.)

An active component of the filipin complex; reduces growth of various fungi (MICs = 1-10 μg/ml); inhibits ADP-stimulated respiration in rat liver mitochondria at 3.5 mg/ml; induces hemolysis of liposomes in a...

Sporidesmolide V

Reference: 25531-2,5

€0.00 (tax incl.)

A cyclodepsipeptide fungal metabolite

TPU-0037A

Reference: 25761-2,5

€0.00 (tax incl.)

An antibiotic; inhibits the growth of Gram-positive bacteria, including MRSA, B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml)

Gilvocarcin M

Reference: 25762-2,5

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An antibiotic; active against S. aureus bacteria at 32 µg/ml; inhibits growth of KB cells (IC50 = 0.52 µg/ml); intercalates into bacteriophage PM2 DNA; toxic to rats (LD50 = 450 mg/kg, i.v.)

Ajoene

Reference: 26242-2,5

€0.00 (tax incl.)

A disulfide with diverse biological activities; active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml); cytotoxic to mouse melanoma...

Lachnone A

Reference: 26462-2,5

€0.00 (tax incl.)

A fungal metabolite; inactive against P. falciparum, C. albicans, and M. tuberculosis; not cytotoxic to KB or BC-1 cells

7-hydroxy Pestalotin

Reference: 26523-2,5

€0.00 (tax incl.)

A fungal metabolite; phytotoxic against a variety of plants

Sporidesmolide III

Reference: 26593-2,5

€0.00 (tax incl.)

A cyclodepsipeptide

Febuxostat Acyl Glucuronide

Reference: 26599-2,5

€0.00 (tax incl.)

A metabolite of febuxostat; is formed via glucuronidation of febuxostat by UGTs

Paraherquamide E

Reference: 26680-2,5

€0.00 (tax incl.)

A fungal metabolite with anthelmintic and insecticidal activities; lethal to C. elegans (LD50 = 6 μg/ml); lethal to O. fasciatus (LD50 = 0.089 μg/nymph); oral administration reduces T. colubriformis fecal egg count in...

Thiocillin I

Reference: 26681-2,5

€0.00 (tax incl.)

An antibiotic originally isolated from Bacillus; has activity against Gram-positive, but not Gram-negative, bacteria; inhibits the growth of B. subtilis, B. anthracis, S. aureus, S. pyogenes, and S. pneumoniae strains...

Quadrone

Reference: 26688-2,5

€0.00 (tax incl.)

A sesquiterpene originally isolated from A. terreus; cytotoxic to human carcinoma KB cells in vitro (EC50 = 1.3 μg/ml)

L-681,217

Reference: 26689-2,5

€0.00 (tax incl.)

An antibiotic; active against Gram positive and Gram negative bacteria at 255 µg/ml; inhibits bacterial protein synthesis (EC50 = 0.4 µM in E. coli); increases EF-Tu-associated GTPase activity (EC50 = 6 µM in E. coli)

Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Reference: 27107-2,5

€0.00 (tax incl.)

A synthetic Aβ peptide that lacks 14 C-terminal amino acids; more soluble than Aβ42; forms fibrils and plaques in vitro that are similar to those formed by Aβ42; induces learning deficits in a passive avoidance task...

Ac-VDVAD-pNA (trifluoroacetate salt)

Reference: 27134-2,5

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A colorimetric caspase-2 substrate; cleavage of the VDVAD peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of caspase-2 activity; can also be cleaved, with lower...

ACTH (18-39) (human)

Reference: 27274-2,5

€0.00 (tax incl.)

A C-terminal peptide fragment of ACTH; produced via processing of ACTH in the intermediate lobe of the pituitary gland; increases cumulative food intake in fasted, but not fed, rats at 2.5 nmol/animal,...

Diclofenac Acyl-β-D-Glucuronide allyl ester

Reference: 27828-2,5

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An intermediate in the synthesis of diclofenac acyl-β-D-glucuronide

4-hydroxy Valsartan

Reference: 27849-2,5

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A major metabolite of valsartan; reduces epinephrine and collagen-induced platelet aggregation in human whole blood

Saroglitazar

Reference: 27851-2,5

€0.00 (tax incl.)

A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin...

Spinosyn D aglycone

Reference: 27937-2,5

€0.00 (tax incl.)

An aglycone form of spinosyn D; not lethal to H. virescens (tobacco budworm) neonate larvae (LC50 = >64 ppm)

TAN 1364B

Reference: 27964-2,5

€0.00 (tax incl.)

A PTP inhibitor; inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively)

3'-Ethoxy Spinosyn L 17-pseudoaglycone

Reference: 27965-2,5

€0.00 (tax incl.)

An acid degradation product of 3’-ethoxy-5,6-dihydrospinosyn L; has no insecticidal activity against the tobacco budworm up to 64 ppm

Spinosyn D 17-pseudoaglycone

Reference: 27975-2,5

€0.00 (tax incl.)

A hydrolysis product of spinosyn D; not lethal to tobacco budworms (H. virescens) at concentrations up to 64 ppm

Sultriecin

Reference: 27976-2,5

€0.00 (tax incl.)

A fungal metabolite; active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml); cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml,...

Deacetylravidomycin

Reference: 27991-2,5

€0.00 (tax incl.)

A microbial metabolite with light-dependent antibiotic and anticancer activities; active against Gram-positive bacteria including B. subtilis, S. aureus, S. epidermidis, and E. faecalis (MICs = 0.78-1.56 and

Eprinomectin B1b

Reference: 27994-2,5

€0.00 (tax incl.)

A minor component of eprinomectin

10'-Desmethoxystreptonigrin

Reference: 28065-2,5

€0.00 (tax incl.)

An antibiotic; active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively); cytotoxic to HCT116 colon and...

Neoaureothin

Reference: 28091-2,5

€0.00 (tax incl.)

A bacterial metabolite; an AR antagonist that inhibits binding of DHT to ARs (IC50 = 13 μM); inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM); is cytotoxic to A549, HCT116,...

SCH 38519

Reference: 28092-2,5

€0.00 (tax incl.)

A fungal metabolite; inhibits thrombin-induced aggregation, as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 µg/ml, respectively); inhibits the growth of various Gram-negative and...

Saccharocarcin A

Reference: 28094-2,5

€0.00 (tax incl.)

An antibiotic; active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay; inhibits C. trachomatis infection in McCoy cells,,

Nybomycin

Reference: 28099-2,5

€0.00 (tax incl.)

A fungal metabolite with antibacterial activity; active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively); active against M....

1-Alaninechlamydocin

Reference: 28102-2,5

€0.00 (tax incl.)

An HDAC inhibitor; reduces total HDAC activity in HeLa cell lysates; reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively)

TAN 420E

Reference: 28120-2,5

€0.00 (tax incl.)

A bacterial metabolite; scavenges DPPH radicals in vitro (IC50 = 1.3 μM); reduces TBARS in rat liver microsomes by 72% at 100 μg/ml; is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100...

Geninthiocin A

Reference: 28125-2,5

€0.00 (tax incl.)

A cyclic thiopeptide bacterial metabolite; active against a variety of Gram-positive bacteria (MICs = 0.2-4 µg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 µg/ml), and the fungus M. hiemalis (MIC = 38...

Avenaciolide

Reference: 28128-2,5

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A fungal metabolite; inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM)

Desotamide

Reference: 28129-2,5

€0.00 (tax incl.)

A cyclic hexapeptide antibiotic; active against S. aureus, S. pneumoniae, and MRSE (MICs = 16, 12.5, and 32 μg/ml, respectively)

Decatromicin B

Reference: 28132-2,5

€0.00 (tax incl.)

A bacterial metabolite; active against Gram-positive bacteria, including several strains of S. aureus (MICs = 0.39-0.78 µg/ml), two strains of MRSA (MICs = 0.39 and 0.78 µg/ml), as well as M. luteus, B. subtilis, and...

Sporidesmolide II

Reference: 28133-2,5

€0.00 (tax incl.)

A cyclic depsipeptide,

Telomycin

Reference: 28137-2,5

€0.00 (tax incl.)

A macrocyclic peptide lactone antibiotic; active against Gram-positive bacteria, including S. aureus, MRSA, and E. faecium (MICs = 4, 2, and 16 µg/ml, respectively); eradicates B. anserina spirochetosis infection in...

Quinaldopeptin

Reference: 28167-2,5

€0.00 (tax incl.)

A quinomycin antibiotic; active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 µg/ml, respectively);...

Leucinostatin A

Reference: 28190-2,5

€0.00 (tax incl.)

A fungal metabolite with diverse biological activities; active against various fungi and bacteria in a disc assay; reduces TPA- and anti-CD3 antibody-induced T cell activation from 0.1-1 μg/ml; inhibits proliferation...

Methylspinazarin

Reference: 29898-2,5

€0.00 (tax incl.)

A bacterial metabolite and COMT inhibitor (IC50 = 0.8 μg/ml); selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml; decreases blood pressure in spontaneously...

Polygodial pyridazine

Reference: 29900-2,5

€0.00 (tax incl.)

A derivative of polygodial; inhibits the growth of MCF-7 and Hs 683 cells (GI50s = 72 and 93 μM, respectively)

Byssochlamic Acid

Reference: 29908-2,5

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A mycotoxin; lethal to mice (LD50 = 94 mg/kg)

Aszonapyrone A

Reference: 29940-2,5

€0.00 (tax incl.)

A meroditerpene fungal metabolite with diverse biological activities; inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively); active against...

Territrem A

Reference: 29941-2,5

€0.00 (tax incl.)

A mycotoxin originally isolated from A. terreus; irreversibly inhibits AChE (IC50 = 24 nM for the electric eel enzyme); induces tremors in mice with a median tremulous dose of 0.31 mg/kg; LD50 = 17.6 mg/kg

Monomethylsulochrin

Reference: 29942-2,5

€0.00 (tax incl.)

A fungal metabolite; active against H. pylori (MIC = 10 µg/ml)

Chevalone E

Reference: 29948-2,5

€0.00 (tax incl.)

A meroterpene; has been found in A. similanensis

Novobiocic Acid

Reference: 29966-2,5

€0.00 (tax incl.)

An aglycone form of novobiocin

Asperfuran

Reference: 29989-2,5

€0.00 (tax incl.)

A fungal metabolite; inhibits the growth of 23 fungi in a disc assay at 50 µg per disc; inhibits chitin synthase (IC50 = 300 µM); inhibits proliferation of HeLa S3 and L1210 cancer cells (IC50s = 25 µg/ml for both)

(–)-Himgaline

Reference: 29990-2,5

€0.00 (tax incl.)

An alkaloid; has been found in G. belgraveana

Himandridine

Reference: 30055-2,5

€0.00 (tax incl.)

An alkaloid

Himbosine

Reference: 30056-2,5

€0.00 (tax incl.)

An alkaloid; has been found in H. baccata bark

Janthitrem A

Reference: 30166-2,5

€0.00 (tax incl.)

A mycotoxin; induces tremors in mice and decreases the time to fall from the rotarod at 4 mg/kg; reduces W. cervinata larvae weight gain and food consumption at 20 µg/g

Pikromycin

Reference: 31331-2,5

€0.00 (tax incl.)

A macrolide antibiotic; active against E. coli, S. aureus, and B. subtilis (MIC99s = 50-60, 90-100, and 25-30 µM, respectively)

Beauveriolide III

Reference: 31775-2,5

€0.00 (tax incl.)

A cyclodepsipeptide inhibitor of lipid droplet formation; inhibits lipid droplet formation at 3 and 10 µM and inhibits cholesterol synthesis (IC50 = 0.41 µM) in primary mouse peritoneal macrophages; inhibits ACAT...

Amicoumacin B

Reference: 31777-2,5

€0.00 (tax incl.)

An amicoumacin with quorum-sensing inhibitory activity; active against C. violaceum (MIC = 250 µg/ml); increases the expression of BMP2 in MG-63 cells

S-5751

Reference: 10004030-1

€0.00 (tax incl.)

A selective antagonist of DP1 (Ki = 1.6 nM); blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs

S-5751

Reference: 10004030-5

€0.00 (tax incl.)

A selective antagonist of DP1 (Ki = 1.6 nM); blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs

S-5751

Reference: 10004030-500

€0.00 (tax incl.)

A selective antagonist of DP1 (Ki = 1.6 nM); blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs

Luteolin

Reference: 10004161-10

€0.00 (tax incl.)

A potent flavanoid inhibitor of soybean and reticulocyte 15-LOs (IC50 = 0.6 µM)

Luteolin

Reference: 10004161-100

€0.00 (tax incl.)

A potent flavanoid inhibitor of soybean and reticulocyte 15-LOs (IC50 = 0.6 µM)

Luteolin

Reference: 10004161-50

€0.00 (tax incl.)

A potent flavanoid inhibitor of soybean and reticulocyte 15-LOs (IC50 = 0.6 µM)

Luteolin

Reference: 10004161-500

€0.00 (tax incl.)

A potent flavanoid inhibitor of soybean and reticulocyte 15-LOs (IC50 = 0.6 µM)

Apoptosis Activator 2

Reference: 10004176-10

€0.00 (tax incl.)

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

Apoptosis Activator 2

Reference: 10004176-25

€0.00 (tax incl.)

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

Apoptosis Activator 2

Reference: 10004176-5

€0.00 (tax incl.)

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

Apoptosis Activator 2

Reference: 10004176-50

€0.00 (tax incl.)

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

CAY10443

Reference: 10004177-10

€0.00 (tax incl.)

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay,

CAY10443

Reference: 10004177-25

€0.00 (tax incl.)

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay,

CAY10443

Reference: 10004177-5

€0.00 (tax incl.)

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay,

CAY10443

Reference: 10004177-50

€0.00 (tax incl.)

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay,

NESS 0327

Reference: 10004184-1

€0.00 (tax incl.)

An extremely potent cannabinoid receptor antagonist with high selectivity for the central CB1 receptor (Ki = 0.35 pM) compared to the peripheral CB2 receptor (Ki = 21 nM)

NESS 0327

Reference: 10004184-10

€0.00 (tax incl.)

An extremely potent cannabinoid receptor antagonist with high selectivity for the central CB1 receptor (Ki = 0.35 pM) compared to the peripheral CB2 receptor (Ki = 21 nM)

NESS 0327

Reference: 10004184-5

€0.00 (tax incl.)

An extremely potent cannabinoid receptor antagonist with high selectivity for the central CB1 receptor (Ki = 0.35 pM) compared to the peripheral CB2 receptor (Ki = 21 nM)

3,4',5-Trismethoxybenzophenone

Reference: 10004185-10

€0.00 (tax incl.)

An analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol

3,4',5-Trismethoxybenzophenone

Reference: 10004185-100

€0.00 (tax incl.)

An analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol

3,4',5-Trismethoxybenzophenone

Reference: 10004185-25

€0.00 (tax incl.)

An analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol

3,4',5-Trismethoxybenzophenone

Reference: 10004185-50

€0.00 (tax incl.)

An analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol

(S)-Flurbiprofen

Reference: 10004207-1

€0.00 (tax incl.)

The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2, respectively); inhibits the release of 6-keto-PGF1α and TXB2 from rat whole blood, gastric mucosa, lung, and jejunal tissue ex...

(S)-Flurbiprofen

Reference: 10004207-100

€0.00 (tax incl.)

The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2, respectively); inhibits the release of 6-keto-PGF1α and TXB2 from rat whole blood, gastric mucosa, lung, and jejunal tissue ex...

(S)-Flurbiprofen

Reference: 10004207-250

€0.00 (tax incl.)

The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2, respectively); inhibits the release of 6-keto-PGF1α and TXB2 from rat whole blood, gastric mucosa, lung, and jejunal tissue ex...

(S)-Flurbiprofen

Reference: 10004207-500

€0.00 (tax incl.)

The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2, respectively); inhibits the release of 6-keto-PGF1α and TXB2 from rat whole blood, gastric mucosa, lung, and jejunal tissue ex...