AM3102 Reference: 13452-10 An OEA analog that stimulates PPARα transcriptional activity (EC50 = 100 nM) and prolongs feeding latency in rodents (ED50 = 2.4 mg/kg); as potent as OEA yet resistant to enzymatic hydrolysis; demonstrates weak affinity for the CB1 and CB2 receptors (Ki = 33 and 26 µM, respectively
D-NMAPPD Reference: 10006305-10 A ceramidase inhibitor; induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner; increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells; reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models at 75 mg/kg
AM3102 Reference: 13452-100 An OEA analog that stimulates PPARα transcriptional activity (EC50 = 100 nM) and prolongs feeding latency in rodents (ED50 = 2.4 mg/kg); as potent as OEA yet resistant to enzymatic hydrolysis; demonstrates weak affinity for the CB1 and CB2 receptors (Ki = 33 and 26 µM, respectively
D-NMAPPD Reference: 10006305-5 A ceramidase inhibitor; induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner; increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells; reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models at 75 mg/kg
AM3102 Reference: 13452-5 An OEA analog that stimulates PPARα transcriptional activity (EC50 = 100 nM) and prolongs feeding latency in rodents (ED50 = 2.4 mg/kg); as potent as OEA yet resistant to enzymatic hydrolysis; demonstrates weak affinity for the CB1 and CB2 receptors (Ki = 33 and 26 µM, respectively
D-NMAPPD Reference: 10006305-50 A ceramidase inhibitor; induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner; increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells; reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models at 75 mg/kg