Reagents (1189)

BDP-4

Reference: HY-D1452

€0.00 (tax incl.)

BDP-4 is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma.

3-Mercaptopropionic acid NHS ester

Reference: HY-136159

€0.00 (tax incl.)

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Hemigossypol

Reference: HY-114595

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Hemigossypol (Isohemigossypol) is a sesquiterpene natural product that can be isolated from Gossypium barbadense. Hemigossypol has antifungal activity.

Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses...

D18024

Reference: HY-U00210

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D18024 is a phthalazinonderivat antiallergic and antihistaminic activity.

S.pombe lumazine synthase-IN-1

Reference: HY-44688

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S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively.

(4-Nitrophenyl)(phenyl)methanone-d5

Reference: HY-W012294S

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(4-Nitrophenyl)(phenyl)methanone-d5 is the deuterium labeled (4-Nitrophenyl)(phenyl)methanone[1].

STAT3-IN-9

Reference: HY-146666

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STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M...

Allyl heptanoate

Reference: HY-W016976

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Allyl heptanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Dimethyl malonate

Reference: HY-Y1787

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Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.

trans-Communic acid

Reference: HY-N3612A

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trans-Communic acid is a diterpenoid. trans-Communic acid can be isolated from ethyl acetate extract of young cones of hinoki (Chamaecyparis obtusa Endl.).

β-Lactamase-IN-1

Reference: HY-19773

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β-Lactamase-IN-1 is an inhibitor of β-Lactamase extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the...

Miriplatin (hydrate)

Reference: HY-16325

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Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.

Thalidomide-PEG4-COOH

Reference: HY-138774

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Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

SYY-B085-1

Reference: HY-138945

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SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1.

4-Nitroso hydrochlorothiazide-13C,15N2,d2

Reference: HY-144140S

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4-Nitroso hydrochlorothiazide-13C,15N2,d2 is the deuterium, 13C-, and 15-labeled 4-Nitroso hydrochlorothiazide[1].

m-Cyanobenzoic acid-13C6

Reference: HY-Y0589S

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m-Cyanobenzoic acid-13C6 is the 13C labeled m-Cyanobenzoic acid[1].

KRIBB11

Reference: HY-100872

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KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.

Thalidomide-PEG2-NH2

Reference: HY-133484

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Thalidomide-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

1-Naphthol-d8

Reference: HY-Y1309S

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1-Naphthol-d8 is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

Ethyl linoleate-13C18

Reference: HY-W013812S

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Ethyl linoleate-13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].

N3-Pen-Dtpp

Reference: HY-151725

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N3-Pen-Dtpp is a click chemistry reagent containing an azide group.

CrBKA

Reference: HY-153104

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CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity.

N3-L-Lys(Boc)-OH

Reference: HY-151841

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N3-L-Lys(Boc)-OH is a click chemistry reagent containing an azide group.

EGFR-IN-54

Reference: HY-146474

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EGFR-IN-54 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 1.623 µM. EGFR-IN-54 shows cytotoxic activity against cancer cell lines.

Pinoresinol 4-O-β-D-glucopyranoside

Reference: HY-N2168

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Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is the major active furofuran type lignans in Fructus Forsythiae. Pinoresinol 4-O-β-D-glucopyranoside shows antioxidant, blood pressure...

Naratriptan-d3

Reference: HY-B0197S

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Naratriptan-d3 is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].

m7GpppAmpG ammonium

Reference: HY-145974A

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m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90%.

Thalidomide-5-PEG4-NH2 hydrochloride

Reference: HY-138785A

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Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

MZP-54

Reference: HY-112376

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MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2.

BTL-105

Reference: HY-129780

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BTL-105 is a monobiotinylated Phos-tag derivative for the detection of phosphopeptides and phosphoproteins.

Benzyl alcohol-α-13C-α,α-d2

Reference: HY-B0892S

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Benzyl alcohol-α-13C-α,α-d2 is the 13C-labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.

PC945

Reference: HY-117766

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PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding...

Trenimon

Reference: HY-105740

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Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction....

Mal-amido-PEG9-Val-Ala-PAB-SG3200

Reference: HY-139956

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Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).

Brexpiprazole

Reference: HY-15780

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Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A...

JNJ-28583113

Reference: HY-149143

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JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death....

BAR502

Reference: HY-101273

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BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

SAG-d3

Reference: HY-12848S

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SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

PPARγ agonist 2

Reference: HY-146742

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PPARγ agonist 2 is a potent PPARγ partial agonist and can be used for metabolic disease research.

A 83-01

Reference: HY-10432

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A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and...

Latrodectus Karrooensis Venom

Reference: HY-N11390

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Latrodectus Karrooensis Venom is a venom that can be obtained from Latrodectus Karrooensis. The venom of the Latrodectus species contains a neurotoxin known as α-latrotoxin, which binds with high affinity to a...

5-Carboxymethyluridine

Reference: HY-152875

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5-Carboxymethyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.

O-Propargyl-Puromycin

Reference: HY-15680

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O-Propargyl-Puromycin, an alkyne analog of puromycin, is a potent protein synthesis inhibitor.

Anticancer agent 70

Reference: HY-147816

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Anticancer agent 70 (Compound 21), an anticancer agent, exhibits remarkable cytotoxic activity against numerous human cancer cell lines. Anticancer agent 70 results in the G0/G1-cell cycle arrest with a concomitant...

PLK1-IN-4

Reference: HY-146792

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PLK1-IN-4 is a potent and selective PLK1 inhibitor with IC50 apoptosis. PLK1-IN-4 can be used for researching hepatocellular carcinoma.

Vepdegestrant

Reference: HY-138642

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Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an...

GB-110

Reference: HY-120528

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GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM.

BAY 1217224

Reference: HY-142661

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BAY 1217224 is a neutral, non-proagent Thrombin inhibitor with good oral pharmacokinetics.

Nortriptyline-d3 hydrochloride

Reference: HY-B1417S

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Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of...

Desmethylcitalopram-d3 hydrochloride

Reference: HY-113739S

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Desmethylcitalopram-d3 (hydrochloride) is the deuterium labeled Desmethylcitalopram hydrochloride[1].

α-2,3-sialyltransferase-IN-1

Reference: HY-112535

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α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM.

Griseofulvin

Reference: HY-17583

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Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

CER3-d9

Reference: HY-146831S

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CER3-d9 is deuterium labeled CER3.

MAT2A inhibitor 4

Reference: HY-139536

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MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A). MAT2A inhibitor 4 can be used for the research of cancer.

Butylated hydroxytoluene-d21

Reference: HY-Y0172S

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Butylated hydroxytoluene-d21 is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a...

AVE 0991 sodium salt

Reference: HY-15778A

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AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM.

Curdione

Reference: HY-N0353

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Curdione, one of the major sesquiterpene compounds from Curcuma zedoaria, has been shown to exhibit multiple bioactive properties.

Octanal

Reference: HY-N8015

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Octanal is an aromatic aldehyde, with antioxidant and antimicrobial activities. Octanal shows cytotoxicity against Hela cells.

Sulfacytine

Reference: HY-16472

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Sulfacytine is a short-acting sulfonamide antibiotic. Sulfacytine is active against bacteria and is an effective agent for the research of acute uncomplicated urinary tract infections.

Raclopride-d5 hydrochloride

Reference: HY-103414S

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Raclopride-d5 (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM,...

Gemcitabine elaidate hydrochloride

Reference: HY-13538A

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Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate...

Fenofibric acid

Reference: HY-B0760

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Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity,...

Triptonide

Reference: HY-32736

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Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression,...

4’,5’-Didehydro-2’-O-methyl-5-methyluridine

Reference: HY-154376

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4’,5’-Didehydro-2’-O-methyl-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely...

Difluprednate

Reference: HY-17569

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Difluprednate is a topical corticosteroid, which is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is used for the symptomatic treatment of inflammation and pain...

Rosiglitazone-d3

Reference: HY-17386S

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Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively....

Amantadine

Reference: HY-B0402

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Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion...

(S,R,S)-AHPC-amido-C7-acid

Reference: HY-148671

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(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.

Anti-Heart Failure Agent 1

Reference: HY-101729

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Anti-Heart Failure Agent 1 an orally available compound suitable for the treatment of heart failure without inducing nausea, vomiting and restlessness.

1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphocholine-d7

Reference: HY-146794S

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1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphocholine-d7 is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phosphocholine.

MsbA-IN-4

Reference: HY-144282

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MsbA-IN-4 (compound 32) is a potent and highly selective MsbA inhibitor with an IC50 value of 3 nM. MsbA-IN-4 has inhibitory activity against Escherichia coli with a MIC of 12 μM.

(-)-Isopulegol

Reference: HY-121206

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(-)-Isopulegol is prepared directly from the treatment of essential oil of citronella under solid supported acid catalysis and solvent-free microwave assisted ene-cyclisation. (-)-Isopulegol shows high activity in...

m-PEG10-azide

Reference: HY-130424

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m-PEG10-azide a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Morantel citrate

Reference: HY-108387

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Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead...

Metoprolol tartrate

Reference: HY-17503B

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Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

Tyrosyltryptophan

Reference: HY-P4655

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Tyrosyltryptophan is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein...

Gambogic Acid

Reference: HY-N0087

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Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM,...

Chitosan (MW 150000)

Reference: HY-B2144A

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Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity,...

Crocin

Reference: HY-N0697

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Crocin (Crocin I) is a nutraceutical and the main constituent isolated from the stigmas of Crocus sativus with immense pharmacological properties as anti-inflammatory, anticancer, antidepressant and anticonvulsant.

Henryoside

Reference: HY-N4054

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Henryoside, an acylated salicin bis-glucoside from Viburnum veitchii, exhibits spasmolytic and uterotonic properties.

Bisphenol AF-d4

Reference: HY-W654077

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Bisphenol AF-d4 is the isotope labelled analog of HY-W013782 Bisphenol AF. Bisphenol AF is a full agonist for the estrogen receptor. Bisphenol AF acts as an endocrine-disrupting chemical (EDC), activating estrogen...

PIPES disodium

Reference: HY-W040147

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PIPES (1,4-Piperazinediethanesulfonic acid) disodium is an important component of PIPES buffer agent used in biochemistry.

N-Mal-N-bis(PEG4-NHS ester)

Reference: HY-140572

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N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Omega-3 arachidonic acid methyl ester

Reference: HY-120978

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omega-3 Arachidonic Acid methyl ester, mainly represented by docosahexaenoic acid, eicosapentaenoic acid and alpha-linoleic acid, are essential dietary nutrients required for normal growth and development. Methyl...

N3-Gly-Gly-OH (DCHA)

Reference: HY-151859A

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N3-Gly-Gly-OH (DCHA) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because...

2"-O-beta-L-galactopyranosylorientin

Reference: HY-N0406

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2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate...

PP7

Reference: HY-100858

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PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including...

Gigantol

Reference: HY-N10549

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Gigantol is a natural product that could be isolated from Cymbidium giganteum. Gigantol is a potent inhibitor of the spontaneous contractions of the guinea-pig ileum.

WIN 64338 hydrochloride

Reference: HY-101368A

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WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells...

Oxypeucedanin

Reference: HY-N0747

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Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac...

S-Ethyl dipropylthiocarbamate-d14

Reference: HY-W019816S

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S-Ethyl dipropylthiocarbamate-d14 is the deuterium labeled S-Ethyl dipropylthiocarbamate[1].

Hirsutenone

Reference: HY-N4042

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Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone...

N-deacetylated BMS-202

Reference: HY-19745A

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N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-1/PD-L1 interaction, mainly used for cancer treatment.

Tarasaponin IV

Reference: HY-N9328

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Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer.

Peginterferon beta-1a

Reference: HY-108790

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Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon...

Clofazimine

Reference: HY-B1046

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Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

ILS-920

Reference: HY-106345

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ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type...

D18

Reference: HY-144501

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D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to...

Zanamivir

Reference: HY-13210

€0.00 (tax incl.)

Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

Category: Reagents

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