Category: Protein

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Reference: GTX00374-pro
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catalyzes conversion of glycine-extended peptides into biologically active alpha-amidated peptides [RGD, Feb 26]
Reference: GTX00375-pro
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growth factor that may be a mediator of TGFbeta1-driven matrix production and normal skeletal remodeling [RGD, Feb 26]
Reference: GTX00376-pro
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This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is...
Reference: GTX00377-pro
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binds the transforming growth factor-beta receptor; plays a role in regulation of cell growth and proliferation; may be involved in mesenchymal-epithelial cell interactions during development [RGD, Feb 26]
Reference: GTX00381-pro
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This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein...
Reference: GTX00385-pro
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human homolog is a cytokine involved in the regulation of T and natural killer cell activation and proliferation [RGD, Feb 26]
Reference: GTX00389-pro
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The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic...
Reference: GTX00391-pro
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This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family...
Reference: GTX00392-pro
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This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family...
Reference: GTX00393-pro
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This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family...
Reference: GTX00397-pro
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This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the...
Reference: GTX00398-pro
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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase...
Reference: GTX00402-pro
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The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq,...
Reference: GTX00408-pro
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human homolog is a heparin-binding growth factor [RGD, Feb 26]
Reference: GTX00410-pro
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an inflammatory cytokine [RGD, Feb 26]
Reference: GTX00411-pro
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factor involved in the inhibition of cytokine synthesis [RGD, Feb 26]
Reference: GTX00412-pro
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Th2-type cytokine; may be involved in inflammatory response in eosinophils [RGD, Feb 26]
Reference: GTX00414-pro
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mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 26]
Reference: GTX00415-pro
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This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided...
Reference: GTX00416-pro
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This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein...
Reference: GTX00417-pro
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The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different...
Reference: GTX00418-pro
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This gene encodes a member of the cytochrome P45 superfamily of enzymes. The cytochrome P45 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids...
Reference: GTX00419-pro
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The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many...
Reference: GTX00420-pro
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 1-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate)...
Reference: GTX00421-pro
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The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal...
Reference: GTX00422-pro
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This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin...
Reference: GTX00424-pro
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This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines...
Reference: GTX00425-pro
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This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the...
Reference: GTX00431-pro
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catalyzes the conversion of biliverdin to bilirubin in heme degradation [RGD, Feb 26]
Reference: GTX00432-pro
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The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction....
Reference: GTX00433-pro
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This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer...
Reference: GTX00434-pro
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The protein encoded by this gene is a member of the heat shock protein 7 (HSP7) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the...
Reference: GTX00435-pro
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The protein encoded by this gene is a member of the heat shock protein 7 (HSP7) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the...
Reference: GTX00437-pro
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catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [RGD, Feb 26]
Reference: GTX00438-pro
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This gene encodes a member of the heat shock protein 7 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as...
Reference: GTX00439-pro
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This gene encodes a member of the small heat shock protein (HSP2) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a...
Reference: GTX00440-pro
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This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly...
Reference: GTX00441-pro
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The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is...
Reference: GTX00442-pro
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This gene encodes a member of the heat shock protein 9 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form...
Reference: GTX00443-pro
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This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 9 (HSP9), localizing to response elements in...
Reference: GTX00444-pro
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This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide...
Reference: GTX00445-pro
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STIP1 is an adaptor protein that coordinates the functions of HSP7 (see HSPA1A; MIM 1455) and HSP9 (see HSP9AA1; MIM 14571) in protein folding. It is thought to assist in the transfer of proteins from HSP7 to HSP9 by...
Reference: GTX00446-pro
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This intronless gene encodes a 7kDa heat shock protein which is a member of the heat shock protein 7 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation...
Reference: GTX00447-pro
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This intronless gene encodes a 7kDa heat shock protein which is a member of the heat shock protein 7 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation...
Reference: GTX00448-pro
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This intronless gene encodes a 7kDa heat shock protein which is a member of the heat shock protein 7 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation...
Reference: GTX00449-pro
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This intronless gene encodes a 7kDa heat shock protein which is a member of the heat shock protein 7 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation...
Reference: GTX00457-pro
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PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 64998) (Gardner et al., 2 [PubMed 1673339]).[supplied by OMIM, Mar 28]
Reference: GTX01205-pro
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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein...
Reference: GTX01206-pro
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Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is...
Reference: GTX01207-pro
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Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is...
Reference: GTX01209-pro-S
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This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons...
Reference: GTX01209-pro
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This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons...
Reference: GTX01210-pro-S
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This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains,...
Reference: GTX01210-pro
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This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains,...
Reference: GTX01211-pro-S
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The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a...
Reference: GTX01211-pro
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The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a...
Reference: GTX01212-pro-S
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The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II...
Reference: GTX01212-pro
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The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II...
Reference: GTX01213-pro-S
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Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly...
Reference: GTX01213-pro
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Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly...
Reference: GTX01214-pro-S
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other...
Reference: GTX01214-pro
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other...
Reference: GTX01215-pro-S
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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and...
Reference: GTX01215-pro
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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and...
Reference: GTX01216-pro-S
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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and...
Reference: GTX01216-pro
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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and...
Reference: GTX01217-pro-S
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This gene encodes a member of the peptidase M1 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as...
Reference: GTX01217-pro
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This gene encodes a member of the peptidase M1 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as...

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