Colibactin Reference: HY-145930 Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. Colibactin has the potential for the research of colorectal cancer[1].
Human Hsp70 protein (active) Reference: GTX00449-pro This intronless gene encodes a 7kDa heat shock protein which is a member of the heat shock protein 7 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 28]
C-telopeptide Reference: HY-P0284 C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).
SKF107457 Reference: HY-120880 SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research.
Human CaMKI beta protein, His tag Reference: GTX00457-pro PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 64998) (Gardner et al., 2 [PubMed 1673339]).[supplied by OMIM, Mar 28]
M617 TFA Reference: HY-P1131A M617 TFA is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617 TFA, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.
Rat Annexin V protein, His tag Reference: GTX00458-pro displays calcium dependent binding to phospholipid membranes [RGD, Feb 26]
Human CDK4 protein, GST tag Reference: GTX01205-pro The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 28]
Mast cell degranulating peptide (28-49) Reference: HY-P1987 Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices.
Human Myeloperoxidase protein, His tag Reference: GTX01206-pro Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 214]