HIP2 blocking peptide Reference: GTX89722-PEP The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 28]
PODS® Human Wnt-9b Reference: PPH342-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-9b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
STUB1 blocking peptide Reference: GTX89724-PEP STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 28 [PubMed 18411298]).[supplied by OMIM, Jul 29]
PODS® Human Wnt-9b Reference: PPH342-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-9b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
FLAP (C Term) blocking peptide Reference: GTX89725-PEP This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 211]
PODS® Human Wnt-10a Reference: PPH343-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-10a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
MSX1 blocking peptide Reference: GTX89726-PEP This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 28]
PODS® Human Wnt-10a Reference: PPH343-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-10a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
FBXO44 blocking peptide Reference: GTX89727-PEP This gene encodes a member of the F-box protein family which is characterized by an approximately 4 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-4 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Four alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jul 28]
PODS® Human Wnt-10a Reference: PPH343-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-10a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
TIF1 alpha blocking peptide Reference: GTX89729-PEP The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 28]
PODS® Human Wnt-10b Reference: PPH344-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-10b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.