GOLPH2 blocking peptide Reference: GTX89715-PEP The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 29]
PODS® Human Wnt-8b Reference: PPH340-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-8b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
PI3 kinase C2 alpha blocking peptide Reference: GTX89716-PEP The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 28]
PODS® Human Wnt-8b Reference: PPH340-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-8b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
Prefoldin 1 blocking peptide Reference: GTX89717-PEP This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 28]
PODS® Human Wnt-9a Reference: PPH341-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-9a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
Bcl-2 blocking peptide Reference: GTX89719-PEP This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 28]
PODS® Human Wnt-9a Reference: PPH341-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-9a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
Annexin A10 blocking peptide Reference: GTX89720-PEP This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 28]
PODS® Human Wnt-9a Reference: PPH341-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-9a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
UBE2L3 blocking peptide Reference: GTX89721-PEP The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p15 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 29]
PODS® Human Wnt-9b Reference: PPH342-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-9b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.