STMN2 blocking peptide Reference: GTX89696-PEP This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 21]
PODS® Human Wnt-5b Reference: PPH336-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-5b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
MCT2 blocking peptide Reference: GTX89697-PEP This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 212]
PODS® Human Wnt-5b Reference: PPH336-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-5b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
NIR1 blocking peptide Reference: GTX89698-PEP This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 29]
PODS® Human Wnt-7a Reference: PPH337-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-7a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
FOXI1 blocking peptide Reference: GTX89700-PEP This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 28]
PODS® Human Wnt-7a Reference: PPH337-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-7a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
alpha Smooth Muscle Actin blocking peptide Reference: GTX89701-PEP The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 28]
PODS® Human Wnt-7a Reference: PPH337-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-7a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
MPP5 blocking peptide Reference: GTX89702-PEP This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 2237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 212]
PODS® Human Wnt-7b Reference: PPH338-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-7b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.