CrkL blocking peptide Reference: GTX89690-PEP This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 29]
PODS® Human Wnt-4 Reference: PPH334-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-4. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
Pirin blocking peptide Reference: GTX89691-PEP This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 28]
PODS® Human Wnt-4 Reference: PPH334-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-4. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.
PODS® Human Wnt-5a Reference: PPH335-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-5a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-5a is expressed by multiple cell types including astrocytes, chondrocytes, mammary epithelium cells, CD34+ primitive progenitor stem cells, chondrocytes, and mesenchymal cells.
PODS® Human Wnt-5a Reference: PPH335-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-5a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-5a is expressed by multiple cell types including astrocytes, chondrocytes, mammary epithelium cells, CD34+ primitive progenitor stem cells, chondrocytes, and mesenchymal cells.
SAMSN1 blocking peptide Reference: GTX89694-PEP SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 21 [PubMed 115365]).[supplied by OMIM, Mar 28]
PODS® Human Wnt-5a Reference: PPH335-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-5a. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-5a is expressed by multiple cell types including astrocytes, chondrocytes, mammary epithelium cells, CD34+ primitive progenitor stem cells, chondrocytes, and mesenchymal cells.
VAV3 blocking peptide Reference: GTX89695-PEP This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 28]
PODS® Human Wnt-5b Reference: PPH336-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-5b. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.