Retinoid X Receptor beta blocking peptide Reference: GTX89670-PEP This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 212]
PODS® Human VEGF-165 Reference: PPH44-250 The product contains the polyhedrin protein co-crystalized with Human VEGF-165. Vascular Endothelial Growth Factor A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
FNBP1 blocking peptide Reference: GTX89672-PEP The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 28]
PODS® Human VEGF-165 Reference: PPH44-1000 The product contains the polyhedrin protein co-crystalized with Human VEGF-165. Vascular Endothelial Growth Factor A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
CREM blocking peptide Reference: GTX89673-PEP This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 28]
PODS® Human Wnt-1 Reference: PPH330-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-1. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of cell surface receptors and plays a crucial role in the embryonic development and carcinogenesis. Wnt-1 signaling is responsible for stabilizing the intracellular signaling protein β-catenin. For certain cell lines, Wnt-1 supports self-renewal while keeping undifferentiated.
PODS® Human Wnt-1 Reference: PPH330-250 The product contains the polyhedrin protein co-crystalized with Human Wnt-1. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of cell surface receptors and plays a crucial role in the embryonic development and carcinogenesis. Wnt-1 signaling is responsible for stabilizing the intracellular signaling protein β-catenin. For certain cell lines, Wnt-1 supports self-renewal while keeping undifferentiated.
PODS® Human Wnt-1 Reference: PPH330-1000 The product contains the polyhedrin protein co-crystalized with Human Wnt-1. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of cell surface receptors and plays a crucial role in the embryonic development and carcinogenesis. Wnt-1 signaling is responsible for stabilizing the intracellular signaling protein β-catenin. For certain cell lines, Wnt-1 supports self-renewal while keeping undifferentiated.
TIRAP/Mal (Isoform b) blocking peptide Reference: GTX89676-PEP The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 28]
PODS® Human Wnt-2 Reference: PPH331-50 The product contains the polyhedrin protein co-crystalized with Human Wnt-2. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation, through three signaling pathways associated with the Wnt-receptor interaction.